The drug was loaded on to gelatin and was then drawn out in the form of nano fibres through the process of electrospinning. It involves use of electric force to draw out charged threads of polymers into fibres with diameters in the order of some hundred nanometres. In order to improve structural consistency in aqueous conditions, saturated vapours of a chemical called glutaraldehyde were used.
Dr. Chandra Shekhar Sharma, Dr. Saptarshi Majumdar, Mrunalini Gaydhane and Dr. Anindita Laha
Amphotericin B is the drug of choice for fungal infections of the abdomen and heart valves, fungal pneumonia, and kala azar. However, it is costly, causes toxicity and its bioavailability is poor.
The team has also found that the nano-fibrous oral tablet was stable over a wide range of pH, which means that it would not be destroyed in the gastrointestinal track before drug absorption into the blood stream.
Explaining the rationale for using nanofibres to produce the oral tablets, researchers said, “nanofibres – fibres that are a hundred thousand times thinner than the human hair – are increasingly being considered as a medium for controlled release of drug molecules because of their large surface area and porosity”.
The drug was loaded on to gelatin and was then drawn out in the form of nano fibres through the process of electrospinning. It involves use of electric force to draw out charged threads of polymers into fibres with diameters in the order of some hundred nanometres. In order to improve structural consistency in aqueous conditions, saturated vapours of a chemical called glutaraldehyde were used.
Dr. Chandra Shekhar Sharma, Dr. Saptarshi Majumdar, Mrunalini Gaydhane and Dr. Anindita Laha
Amphotericin B is the drug of choice for fungal infections of the abdomen and heart valves, fungal pneumonia, and kala azar. However, it is costly, causes toxicity and its bioavailability is poor.
The team has also found that the nano-fibrous oral tablet was stable over a wide range of pH, which means that it would not be destroyed in the gastrointestinal track before drug absorption into the blood stream.
Explaining the rationale for using nanofibres to produce the oral tablets, researchers said, “nanofibres – fibres that are a hundred thousand times thinner than the human hair – are increasingly being considered as a medium for controlled release of drug molecules because of their large surface area and porosity”.
